Objectives and Guidelines for Phase 1 (2024)

As the name implies, Induction is the initiation into the Atkins Diet. All too often, people confuse this first phase of the program with the whole diet, but Induction is only the first of four progressively liberal phases. The two main objectives of Induction are:

1. To switch the body from burning primarily glucose to burning primarily fat for energy.

2. To jump-start weight loss.

The Basics of Induction

It’s not essential to start Atkins in Phase 1, but its carbohydrate intake level is almost certain to induce lipogenesis. Induction restricts individuals to only 20 grams of Net Carbs (grams of total grams minus grams of fiber—or in the case of low-carb foods, also minus grams of sugar alcohols, including glycerin) per day. Carbohydrate foods consumed in this phase are primarily “foundation vegetables” low in carbs but rich in vitamins, minerals, antioxidants and other nutrients, including fiber. Individuals remain in this phase for at least two weeks.

Many people see remarkably fast weight loss on Induction. Others find it slow going. It’s important to explain this to your patients, as their expectations may be unreasonable. Whatever their pace and whether their objectives is weight loss or improvement of blood sugar and insulin levels or lipids—or some combination of the above, individuals they need to abide by the following rules.

Guidelines for Induction

  • Eat either three regular-size meals a day or four or five smaller meals. Don’t skip meals or go more than six waking hours without eating.
  • At each meal—including breakfast—eat at least 4 to 6 ounces of protein foods. Up to 8 ounces is fine for tall guys. There’s no need to trim the fat from meat or the skin from poultry, but it’s okay to do so if the fat is replaced with some olive oil or butter on vegetables.
  • It’s important to consume butter, olive oil, high-oleic safflower oil, canola oil, and seed and nut oils and mayonnaise (made from olive, canola, or high-oleic safflower oils). Aim for 1 tablespoon of oil on a salad or other vegetables, or a pat of butter. Cook foods in just enough oil to ensure that they don’t burn. Or spritz the pan with a mist of olive oil.
  • Eat no more than 20 grams a day of Net Carbs, 12 to 15 grams of them as foundation vegetables, the equivalent of approximately six loosely packed cups of salad and two cups of cooked vegetables per day. But carb counts of various vegetables vary, so it’s important to check them in the Atkins Comprehensive Carb Counter or at www.atkins.com/Program/FourPhases/CarbCounter.aspx.
  • Eat only foods listed on Acceptable Foods for Phase 1.
  • Avoid all other foods, including sugar, white flour, other refined grains, whole grains, fruit other than avocado, tomatoes and olives, legumes and starchy vegetables, milk in any form and low-fat, low-calorie products or low-carb products (unless specifically coded for Phase 1).
  • In a typical day, carb intake can include up to 4 ounces of most cheese (but not cottage cheese or ricotta), 10 black or 20 green olives, half a Haas avocado (the kind with a blackish pebbly skin), an ounce of sour cream or 2–3 tablespoons of cream, and up to 3 tablespoons of lemon or lime juice. The carbs in these foods must be counted in the 20 grams of Net Carbs.
  • Acceptable sweeteners include sucralose (Splenda), saccharin (Sweet’N Low), stevia (SweetLeaf or Truvia) or xylitol. Have no more than three packets a day, and count each one as 1 gram of carbs. These sweeteners contain no carbs, but they are packaged with fillers that contain a little carbohydrate to keep them from clumping.
  • Sugar-free gelatin desserts and up to two Atkins shakes or bars coded for Induction are allowed.
  • Each day, drink at least eight 8-ounce portions of approved beverages: water, club soda, herb teas, or moderation—caffeinated or decaffeinated coffee and tea. This will prevent dehydration and electrolyte imbalances. This count can include two cups of broth (not low sodium), one in the morning and one in the afternoon.
  • Take a daily iron-free multivitamin/multimineral combo and an omega-3 fatty-acid supplement. If an individual is iron deficient than supplementation is fine.
  • Learn to distinguish hunger from habit and adjust the quantity as appetite decreases. Eat only until satisfied but not stuffed. If not sure, wait 10 minutes, have a glass of water, and eat more only if still unsatisfied. If not hungry at mealtime, eat a small low-carb snack.
  • No “starving” or skimping on fats is necessary.
  • Don’t assume that any food is low in carbs. Read the labels on packaged whole foods to discover unacceptable ingredients; and check their carb counts (subtract grams of fiber from total grams). Also use a carbohydrate gram counter.
  • When dining out, be on guard for hidden carbs. Gravy is usually made with flour or cornstarch, both unacceptable on Atkins. Sugar is often found in salad dressing and may even appear in coleslaw and other deli salads. Avoid any deep-fried or breaded food.

Meal Planning

Our downloadable One-Week Induction Meal Plan [provide link] makes it easy to plan meals ahead, which is key to success.

Objectives and Guidelines for Phase 1 (2024)

FAQs

What are the objectives of Phase 1 study? ›

A phase I clinical trial tests the safety, side effects, best dose, and timing of a new treatment. It may also test the best way to give a new treatment (for example, by mouth, infusion into a vein, or injection) and how the treatment affects the body.

What is the objective of Phase I? ›

The primary objective of Phase I trials is to evaluate the safety and tolerability of a new treatment. Phase I trials typically involve 10 to 100 participants, and the sample size is determined based on safety considerations.

How to design a phase 1 clinical trial? ›

Designing Phase 1 Clinical Trials

Participant Selection: Phase 1 trials typically involve a small group of healthy volunteers or patients with the specific disease or condition under investigation. The selection criteria ensure that the participants are suitable for evaluating the treatment's safety and dosage.

What is the primary objective of a phase II clinical trial? ›

The primary objective of a phase II clinical trial of a new drug or regimen is to determine whether it has sufficient biological activity against the disease under study to warrant more extensive development.

What are the key objectives of a Phase 1 trial regardless of drugs? ›

The goals of Phase I trials include: (1) exploring the safety of the investigational compound carefully and progressively through gradually increasing doses and durations of exposure; (2) determining the absorption/bioavailability, pharmaco*kinetics, metabolism, and excretion of the compound; and (3) delineating the ...

What is the main objective of a Phase 1 clinical gene therapy trial? ›

Phase I clinical trials provide initial safety data to support further testing with larger samples. As the focus of these studies is primarily safety of investigation rather than efficacy or effectiveness of treatment, the study subjects are frequently a small number of healthy volunteers.

How to conduct a phase 1 trial? ›

A Phase 1 clinical trial is performed over several months in a small group of 20 to 100 healthy volunteers, typically men or those with the disease/condition. These participants will receive a “first in human” single dose of a new drug, usually orally or intravenously, and will be monitored for safety.

What are the components of a Phase 1 clinical trial? ›

A phase I trial design has many components, including starting dose, dose increment, dose escalation method, number of patients per dose level, specification of dose-limiting toxicity, target toxicity level, definition of the maximum tolerated dose (MTD) and recommended dose for phase II trials, patient selection, and ...

What are Phase 1 trials designed to determine? ›

Phase I trials are concerned primarily with establishing a new drug's safety and dose range in about 20-100 healthy volunteers. How a drug is absorbed, distributed, metabolized and excreted by the human body is called Pharmaco*kinetics.

What is the purpose of a Phase I clinical trial to evaluate? ›

Phase I trials are the first studies of an intervention conducted in humans. Phase I trials have small sample sizes (e.g., <20), may enroll healthy human participants, and are used to investigate pharmaco*kinetics, pharmacodynamics, and toxicity.

What is the primary purpose of phase I research? ›

Phase I trials: Researchers test a drug or treatment in a small group of people (20–80) for the first time. The purpose is to study the drug or treatment to learn about safety and identify side effects.

What are the objectives of a clinical trial? ›

A clinical trial aims to find an answer to the main research question or hypothesis that the study plans to answer. Hypothesis testing is the most widely employed method of determining whether clinical study outcomes are positive or negative.

What is phase 1 of an experiment? ›

Phase I trials normally include dose-ranging, also called dose escalation studies, so that the best and safest dose can be found and to discover the point at which a compound is too poisonous to administer. The tested range of doses will usually be a fraction of the dose that caused harm in animal testing.

What is the primary purpose of Phase 1 research quizlet? ›

Phase I research is the first phase of research after animal testing and helps define future phase II and III studies.

What are objectives in clinical trials? ›

Primary Aims/Objectives are the primary goals of the clinical trial, expressed as a statement of purpose (e.g., to assess…; to determine…; to compare…; to evaluate…). They: Drive statistical planning (e.g., sample size calculation / statistical power)

Top Articles
Latest Posts
Article information

Author: Pres. Carey Rath

Last Updated:

Views: 5891

Rating: 4 / 5 (41 voted)

Reviews: 88% of readers found this page helpful

Author information

Name: Pres. Carey Rath

Birthday: 1997-03-06

Address: 14955 Ledner Trail, East Rodrickfort, NE 85127-8369

Phone: +18682428114917

Job: National Technology Representative

Hobby: Sand art, Drama, Web surfing, Cycling, Brazilian jiu-jitsu, Leather crafting, Creative writing

Introduction: My name is Pres. Carey Rath, I am a faithful, funny, vast, joyous, lively, brave, glamorous person who loves writing and wants to share my knowledge and understanding with you.